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BIOCHEMISTRY
3ème année

Bacillus Subtilis

Biologie

Definition

Bacillus Subtilis
Gram-positive, catalase-positive bacterium, found in soil and the gastrointestinal tract of ruminants and humans. As a member of the genus Bacillus, B. subtilis is rod-shaped, and can form a tough, protective endospore, allowing it to tolerate extreme environmental conditions. B. subtilis has historically been classified as an obligate aerobe, though evidence exists that it is a facultative anaerobe. B. subtilis is considered the best studied Gram-positive bacterium and a model organism to study bacterial chromosome replication and cell differentiation. It is one of the bacterial champions in secreted enzyme production and used on an industrial scale by biotechnology companies.

Why is Bacillus Subtilis a good model system ?


  • extremely powerful genetic toolbox
  • easy to cultivate
  • fast growing
  • important industrial organism: proficient at secreting proteins + making small fine chemicals + acting as a plant growth promoter
  • makes endospores (which have provided an exceptionally fruitful system for studying various central problems of cellular development, including the generation of asymmetry, cell fate determination and morphogenesis)
'
BIOCHEMISTRY
3ème année

Bacillus Subtilis

Biologie

Definition

Bacillus Subtilis
Gram-positive, catalase-positive bacterium, found in soil and the gastrointestinal tract of ruminants and humans. As a member of the genus Bacillus, B. subtilis is rod-shaped, and can form a tough, protective endospore, allowing it to tolerate extreme environmental conditions. B. subtilis has historically been classified as an obligate aerobe, though evidence exists that it is a facultative anaerobe. B. subtilis is considered the best studied Gram-positive bacterium and a model organism to study bacterial chromosome replication and cell differentiation. It is one of the bacterial champions in secreted enzyme production and used on an industrial scale by biotechnology companies.

Why is Bacillus Subtilis a good model system ?


  • extremely powerful genetic toolbox
  • easy to cultivate
  • fast growing
  • important industrial organism: proficient at secreting proteins + making small fine chemicals + acting as a plant growth promoter
  • makes endospores (which have provided an exceptionally fruitful system for studying various central problems of cellular development, including the generation of asymmetry, cell fate determination and morphogenesis)
'
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